When one award is not enough!
January 29, 2018
Another three awards go to PhD student Aida Razi in the Ortega lab: McGill MedStar Award for his recent PNAS paper (http://www.pnas.org/content/114/17/E3396.long …), Canadian Foundation for the Development of Microscopy Travel Award and McGill F. Medicine Enhancement Award. Congrats x3!!
The Ortega lab moves to its new space at McGill
September 29, 2017
The Ortega lab moved this week to its new space. Thank you to the Department of Anatomy and Cell Biology for providing such a beautiful space to work and to all the Ortega lab members for the hard work this week to complete the move in three days. Let's the Science begin!
Aida Razi passes toughest McGill exam
August 31, 2017
Aida Razi passed today her comprehensive exam. Graduate students at McGill fear this exam as the toughest at McGill. Aida endured three hour questioning about her project, general biochemistry and cell biology knowledge and also about a scientific paper outside her expertise. She passed with flying colors and received a straight ‘meets the expectations’ (highest mark) in all categories. Well done Aida!
New postdoctoral fellow joins the lab
August 1, 2017
Dr. Maya Ayach joined the lab this week as a postdoctoral fellow. Maya comes from France where she obtained her PhD degree at the University of Strasbourg. Maya brings to the lab extensive expertise in molecular biology, genetics, RNA biochemistry and biophysics. These will be great assets in many of current ribosome biogenesis projects the lab is currently working on. Welcome Maya!
Aida Razi receives the McGill Faculty of Medicine Fellowship Award
August 1, 2017
Aida Razi is this year awardee of the McGill Faculty of Medicine Fellowship. This award is a extremely competitive award that recognizes outstanding students enrolled in the Graduate programs supported by the Faculty of Medicine at McGill. Aida’s stellar publication record, including her recently published PNAS paper on the structure of the 30S+YjeQ complex, made her the deserving winner of this year award. Congratulations Aida!
Dushyant shows exceptional poster presentation skills and wins a second Best Poster presentation award in less than 2 months at McGill
July 7, 2017
PhD student Dushyant Jahagirdar did it again! In less than two months that the lab has been at McGill Dushyant nailed today a second Best Poster award. This time was at the annual retreat of the Department of Anatomy and Cell Biology, our new home Department at McGill. keep going Dushyant!
Xiaodan Ni moves on and joins the MRC LMB for his postdoctoral training
June 23, 2017
Xiaodan Ni who graduated with a PhD degree from the Ortega lab last November will soon join the laboratory of Dr. Roger Williams at the MRC Laboratory of Molecular Biology in Cambridge, UK. During her time in the Ortega lab, Xiaodan made important inroads in several projects aiming to understand the role of GTPases in the assembly of the 50S subunit. In Dr. Williams’ lab Xiaodan will work in a different area of research, but we want to wish her best of luck in this new exciting stage of her training and career.
New funding received from CIHR to boost research in new antimicorbial targets
June 2, 2017
The Ortega lab has renewed its CIHR funding for an additional 5 years. These funds will be used to obtain a better understanding of the structure and function of new antimicrobial targets, developing them into tangible enzymes for intervention with new antibiotics. The new research will focus on the assembly process of the bacterial ribosome, a pathway of tremendous potential but that has not been explored as a target for antimicrobials. The work the Ortega lab will be doing in this project is part of an international collaboration with Dr. Robert Britton at Baylor College of Medicine at Houston and Dr, James Williamson at the Scripps Research Institute in San Diego.
Xiaodan Ni receives her PhD degree
May 25, 2017
Xiaodan Ni received today her PhD degree at convocation today. Xiaodan came to the Ortega lab in 2012 as an international student from China and defended her Thesis last November. Xiaodan now will move to the MRC Cambridge where she will join the laboratory of Dr. Roger Williams. Congratulations Xiaodan!!
Dushyant Jahagirdar wins the award to the best poster presentation at the MSC meeting 2017
May 12, 2017
Dushyant receives his poster award from Dr. Isabelle Rouiller at the banquet closing ceremony of the MSC meeting 2017 in Montreal. Well done Dushyant!
PLOS Biology paper
March 31, 2017
The work contributed by Xiaodan Ni to our collaboration with the group of Dr. Eric Alani at Cornell University will be published in PLOS Biology. The paper was accepted today. The Tittle of the paper is “The meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can capture and cleave DNA substrates “. Stay tuned to the PLOS biology website for the release of the paper very soon.
News and Views article published in EMBO J
March 16, 2017
Our laboratory just published a news and views article in EMBO J. PhD student Aida Razi is first author in this article.
Read the news and views article in:
Our lab moves to McGill University
March 16, 2017
After fourteen years at McMaster the Ortega lab starts a new chapter. Our laboratory is moving to McGill University in Montreal, where it will become part of the Department of Anatomy and Cell Biology. We will miss our many amazing colleagues at McMaster, but we also look forward to the new challenges McGill will bring and to the new colleagues we will have there. PhD students Aida Razi and Dushyant Jahagirdar and MSc student all coming now to McGill celebrate a week of lab packing next to the impressive track taking our lab to Montreal.
Aida’s work on YjeQ gets published in PNAS
March 14, 2017
Aida’s latest work on YjeQ was accepted today for publication in PNAS. This paper represents a great accomplishment for Aida and the Ortega lab. Well done Aida! The paper describes the cryo-EM structure of the mature 30S subunit in complex with the assembly factor YjeQ at ~5 Å resolution. The structure shows how YjeQ test the decoding fidelity of the mature 30S subunit before the particle is released to the pool of actively translating ribosomes. This finding reveals that, in addition to their role as an assembly factor, YjeQ also has a checkpoint function in the context of the mature ribosomal subunit. Understanding the specific functions of factors like YjeQ may assist in identifying key steps of the ribosome assembly pathway that can be leverage as molecular targets for new antibiotics.